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Imaging of pre-mRNA splicing in living subjects using a genetically encoded luciferase reporter

Pre-mRNA splicing is an essential step in gene expression in most eukaryote genes. Here we present the feasibility of a genetically encoded luciferase reporter to monitor the pre-mRNA splicing process in living cells and animals. We showed that the splicing activity change induced by isoginkgetin co...

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Dades bibliogràfiques
Publicat a:Biomed Opt Express
Autors principals: Shi, Yaru, Liu, Wei, Zheng, Haifeng, Li, Zhiqiang, Shi, Xiaorui, Cai, Shixuan, Jiao, Zhiqiang, Mao, Wenjie, Xie, Jinrong, Tian, Jie, Wang, Fu
Format: Artigo
Idioma:Inglês
Publicat: Optical Society of America 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854055/
https://ncbi.nlm.nih.gov/pubmed/29552390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1364/BOE.9.000518
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