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Chemical Inhibition of pre-mRNA Splicing in Living Saccharomyces cerevisiae
The spliceosome mediates precursor mRNA (pre-mRNA) splicing in eukaryotes, including the model organism Saccharomyces cerevisiae (yeast). Despite decades of study, no chemical inhibitors of yeast splicing in vivo are available. We have developed a system to efficiently inhibit splicing and block pro...
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| Publicado en: | Cell Chem Biol |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6430687/ https://ncbi.nlm.nih.gov/pubmed/30639260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.11.008 |
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