A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

BACKGROUND: DSM265 is a selective inhibitor of Plasmodium dihydroorotate dehydrogenase that fully protected against controlled human malarial infection (CHMI) by direct venous inoculation of Plasmodium falciparum sporozoites when administered 1 day before challenge and provided partial protection wh...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Murphy, Sean C, Duke, Elizabeth R, Shipman, Kelly J, Jensen, Ryan L, Fong, Youyi, Ferguson, Sue, Janes, Holly E, Gillespie, Kevin, Seilie, Annette M, Hanron, Amelia E, Rinn, Laurie, Fishbaugher, Matthew, VonGoedert, Tracie, Fritzen, Emma, Kappe, Stefan H, Chang, Ming, Sousa, Jason C, Marcsisin, Sean R, Chalon, Stephan, Duparc, Stephan, Kerr, Nicola, Möhrle, Jörg J, Andenmatten, Nicole, Rueckle, Thomas, Kublin, James G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853383/
https://ncbi.nlm.nih.gov/pubmed/29216395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix613
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