A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

BACKGROUND: DSM265 is a selective inhibitor of Plasmodium dihydroorotate dehydrogenase that fully protected against controlled human malarial infection (CHMI) by direct venous inoculation of Plasmodium falciparum sporozoites when administered 1 day before challenge and provided partial protection wh...

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Bibliografische gegevens
Gepubliceerd in:J Infect Dis
Hoofdauteurs: Murphy, Sean C, Duke, Elizabeth R, Shipman, Kelly J, Jensen, Ryan L, Fong, Youyi, Ferguson, Sue, Janes, Holly E, Gillespie, Kevin, Seilie, Annette M, Hanron, Amelia E, Rinn, Laurie, Fishbaugher, Matthew, VonGoedert, Tracie, Fritzen, Emma, Kappe, Stefan H, Chang, Ming, Sousa, Jason C, Marcsisin, Sean R, Chalon, Stephan, Duparc, Stephan, Kerr, Nicola, Möhrle, Jörg J, Andenmatten, Nicole, Rueckle, Thomas, Kublin, James G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Major Articles and Brief Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853383/
https://ncbi.nlm.nih.gov/pubmed/29216395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix613
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