A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

BACKGROUND: DSM265 is a selective inhibitor of Plasmodium dihydroorotate dehydrogenase that fully protected against controlled human malarial infection (CHMI) by direct venous inoculation of Plasmodium falciparum sporozoites when administered 1 day before challenge and provided partial protection wh...

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書目詳細資料
發表在:J Infect Dis
Main Authors: Murphy, Sean C, Duke, Elizabeth R, Shipman, Kelly J, Jensen, Ryan L, Fong, Youyi, Ferguson, Sue, Janes, Holly E, Gillespie, Kevin, Seilie, Annette M, Hanron, Amelia E, Rinn, Laurie, Fishbaugher, Matthew, VonGoedert, Tracie, Fritzen, Emma, Kappe, Stefan H, Chang, Ming, Sousa, Jason C, Marcsisin, Sean R, Chalon, Stephan, Duparc, Stephan, Kerr, Nicola, Möhrle, Jörg J, Andenmatten, Nicole, Rueckle, Thomas, Kublin, James G
格式: Artigo
語言:Inglês
出版: Oxford University Press 2018
主題:
Major Articles and Brief Reports
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853383/
https://ncbi.nlm.nih.gov/pubmed/29216395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix613
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