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Conversion of monomeric protein L to an obligate dimer by computational protein design
Protein L consists of a single α-helix packed on a four-stranded β-sheet formed by two symmetrically opposed β-hairpins. We use a computer-based protein design procedure to stabilize a domain-swapped dimer of protein L in which the second β-turn straightens and the C-terminal strand inserts into the...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The National Academy of Sciences
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC58527/ https://ncbi.nlm.nih.gov/pubmed/11526208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181354398 |
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