Conversion of monomeric protein L to an obligate dimer by computational protein design

Protein L consists of a single α-helix packed on a four-stranded β-sheet formed by two symmetrically opposed β-hairpins. We use a computer-based protein design procedure to stabilize a domain-swapped dimer of protein L in which the second β-turn straightens and the C-terminal strand inserts into the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kuhlman, Brian, O'Neill, Jason W., Kim, David E., Zhang, Kam Y. J., Baker, David
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11526208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.181354398
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