SK channel enhancers attenuate Ca(2+)-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR

AIMS: Plasmamembrane small conductance Ca(2+)-activated K(+ )(SK) channels were implicated in ventricular arrhythmias in infarcted and failing hearts. Recently, SK channels were detected in the inner mitochondria membrane (IMM) (mSK), and their activation protected from acute ischaemia-reperfusion i...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Kim, Tae Yun, Terentyeva, Radmila, Roder, Karim H. F., Li, Weiyan, Liu, Man, Greener, Ian, Hamilton, Shanna, Polina, Iuliia, Murphy, Kevin R., Clements, Richard T., Dudley, Samuel C., Koren, Gideon, Choi, Bum-Rak, Terentyev, Dmitry
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852621/
https://ncbi.nlm.nih.gov/pubmed/28096168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx005
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