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Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity

Botulinum neurotoxins (BoNTs) are among the most potent toxins known and are also used to treat an increasing number of medical disorders. There are seven well-established serotypes (BoNT/A-G), which all act as zinc-dependent endopeptidases targeting specific members of the SNARE proteins required f...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Masuyer, Geoffrey, Zhang, Sicai, Barkho, Sulyman, Shen, Yi, Henriksson, Linda, Košenina, Sara, Dong, Min, Stenmark, Pål
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851995/
https://ncbi.nlm.nih.gov/pubmed/29540745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22842-4
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