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Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity

Botulinum neurotoxins (BoNTs) are among the most potent toxins known and are also used to treat an increasing number of medical disorders. There are seven well-established serotypes (BoNT/A-G), which all act as zinc-dependent endopeptidases targeting specific members of the SNARE proteins required f...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Masuyer, Geoffrey, Zhang, Sicai, Barkho, Sulyman, Shen, Yi, Henriksson, Linda, Košenina, Sara, Dong, Min, Stenmark, Pål
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851995/
https://ncbi.nlm.nih.gov/pubmed/29540745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22842-4
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