Scleroderma keratinocytes promote fibroblast activation independent of transforming growth factor beta

OBJECTIVES: SSc is a devastating disease that results in fibrosis of the skin and other organs. Fibroblasts are a key driver of the fibrotic process through deposition of extracellular matrix. The mechanisms by which fibroblasts are induced to become pro-fibrotic remain unclear. Thus, we examined th...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: McCoy, Sara S, Reed, Tamra J, Berthier, Celine C, Tsou, Pei-Suen, Liu, Jianhua, Gudjonsson, Johann E, Khanna, Dinesh, Kahlenberg, J Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Clinical Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850806/
https://ncbi.nlm.nih.gov/pubmed/28968684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kex280
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