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Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts

OBJECTIVE: Emerging evidence supports a role for epigenetic regulation in the pathogenesis of scleroderma (SSc). We aimed to assess the role of methyl-CpG-binding protein 2 (MeCP2), a key epigenetic regulator, in fibroblast activation and fibrosis in SSc. METHODS: Dermal fibroblasts were isolated fr...

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Bibliographische Detailangaben
Veröffentlicht in:Ann Rheum Dis
Hauptverfasser: He, Ye, Tsou, Pei-Suen, Khanna, Dinesh, Sawalha, Amr H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297461/
https://ncbi.nlm.nih.gov/pubmed/29760157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-213022
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