Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies

BACKGROUND: The aetiology of systemic sclerosis (SSc) is not clear, but there is an emerging evidence of gene-specific epigenetic dysregulation in the pathogenesis of SSc. METHODS: We performed a genome-wide DNA methylation study in dermal fibroblasts in six diffuse cutaneous SSc (dSSc) patients, si...

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Bibliografiske detaljer
Udgivet i:Ann Rheum Dis
Main Authors: Altorok, Nezam, Tsou, Pei-Suen, Coit, Patrick, Khanna, Dinesh, Sawalha, Amr H
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224992/
https://ncbi.nlm.nih.gov/pubmed/24812288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-205303
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