Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Mutational inactivation of the SWI/SNF chromatin regulator ATRX occurs frequently in gliomas, the most common primary brain tumors. Whether and how ATRX deficiency promotes oncogenesis by epigenomic dysregulation remains unclear, despite its recent implication in both genomic instability and telomer...

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Foilsithe in:Nat Commun
Main Authors: Danussi, Carla, Bose, Promita, Parthasarathy, Prasanna T., Silberman, Pedro C., Van Arnam, John S., Vitucci, Mark, Tang, Oliver Y., Heguy, Adriana, Wang, Yuxiang, Chan, Timothy A., Riggins, Gregory J., Sulman, Erik P., Lang, Frederick F., Creighton, Chad J., Deneen, Benjamin, Miller, C. Ryan, Picketts, David J., Kannan, Kasthuri, Huse, Jason T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849741/
https://ncbi.nlm.nih.gov/pubmed/29535300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03476-6
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