Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Mutational inactivation of the SWI/SNF chromatin regulator ATRX occurs frequently in gliomas, the most common primary brain tumors. Whether and how ATRX deficiency promotes oncogenesis by epigenomic dysregulation remains unclear, despite its recent implication in both genomic instability and telomer...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Danussi, Carla, Bose, Promita, Parthasarathy, Prasanna T., Silberman, Pedro C., Van Arnam, John S., Vitucci, Mark, Tang, Oliver Y., Heguy, Adriana, Wang, Yuxiang, Chan, Timothy A., Riggins, Gregory J., Sulman, Erik P., Lang, Frederick F., Creighton, Chad J., Deneen, Benjamin, Miller, C. Ryan, Picketts, David J., Kannan, Kasthuri, Huse, Jason T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849741/
https://ncbi.nlm.nih.gov/pubmed/29535300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03476-6
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia