CADD-27. G-QUADRUPLEX DNA DRIVES GENOMIC INSTABILITY AND REPRESENTS A TARGETABLE MOLECULAR ABNORMALITY IN ATRX-DEFICIENT MALIGNANT GLIOMA

Mutational inactivation of ATRX (a-thalassemia mental retardation X-linked) represents a defining molecular alteration in large subsets of malignant glioma. ATRX encodes a chromatin binding protein widely implicated in epigenetic regulation and remodeling. However, multiple studies have also associa...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Wang, Yuxiang, Yang, Jie, Wu, Wei, Shah, Rachna, Danussi, Carla, Riggins, Gregory, Kannan, Kasthuri, Sulman, Erik, Chan, Timothy, Huse, Jason
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216854/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1168
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki