CADD-27. G-QUADRUPLEX DNA DRIVES GENOMIC INSTABILITY AND REPRESENTS A TARGETABLE MOLECULAR ABNORMALITY IN ATRX-DEFICIENT MALIGNANT GLIOMA

Mutational inactivation of ATRX (a-thalassemia mental retardation X-linked) represents a defining molecular alteration in large subsets of malignant glioma. ATRX encodes a chromatin binding protein widely implicated in epigenetic regulation and remodeling. However, multiple studies have also associa...

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Publicado no:Neuro Oncol
Main Authors: Wang, Yuxiang, Yang, Jie, Wu, Wei, Shah, Rachna, Danussi, Carla, Riggins, Gregory, Kannan, Kasthuri, Sulman, Erik, Chan, Timothy, Huse, Jason
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216854/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1168
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