GENE-24. ATRX DEFICIENCY IN GLIOMA CELLS OF ORIGIN PROMOTES DISEASE-DEFINING PHENOTYPES BY WAY OF GLOBAL EPIGENOMIC REMODELING

Epigenomic abnormalities are increasingly recognized as driver mechanisms in cancer, and somatic mutations in genes encoding epigenetic regulators have now been widely reported across a number of cancer types. Diffusely infiltrating gliomas, feature loss-of function mutations in the SWI/SNF chromati...

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Vydáno v:Neuro Oncol
Hlavní autoři: Danussi, Carla, Bose, Promita, Parthasarathy, Prasanna, Silberman, Pedro, Van Arnam, John S, Vitucci, Mark, Tang, Oliver, Heguy, Adriana, Chan, Timothy, Sulman, Erik, Lang, Fred, Creighton, Chad J, Deneen, Benjamin, Miller, C Ryan, Picketts, David, Kannan, Kasthuri, Huse, Jason
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692620/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.398
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