GENE-37. ATRX INACTIVATION DISRUPTS GLOBAL HETEROCHROMATIN LANDSCAPES AND ALTERS DISEASE-RELEVANT TRANSCRIPTIONAL ACTIVITY

Diffusely infiltrating gliomas feature loss-of function mutations in the SWI/SNF chromatin remodeler gene ATRX as defining molecular alterations delineating major adult and pediatric disease subtypes. So far, ATRX inactivation in cancer has been mainly correlated with alternative lengthening of telo...

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Published in:Neuro Oncol
Main Authors: Danussi, Carla, Singh, Anand K, Fischer, Grant, Picketts, David J, Kannan, Kasthuri, Rai, Kunal, Huse, Jason T
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216860/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.463
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