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Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors
The anti-apoptotic protein survivin is highly expressed in cancer cells but has a very low expression in fully differentiated adult cells. Overexpression of survivin is positively correlated with cancer cell resistance to chemotherapy and radiotherapy, cancer cell metastasis, and poor patient progno...
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| Veröffentlicht in: | Eur J Med Chem |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5849576/ https://ncbi.nlm.nih.gov/pubmed/29501942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.02.045 |
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