Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities

Colchicine binding site inhibitors (CBSIs) hold great potential in developing new generations of antimitotic drugs. Unlike existing tubulin inhibitors such as paclitaxel, they are generally much less susceptible to resistance caused by the overexpression of drug efflux pumps. The 3,4,5-trimethoxyphe...

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Publicado no:J Med Chem
Main Authors: Wang, Qinghui, Arnst, Kinsie E., Wang, Yuxi, Kumar, Gyanendra, Ma, Dejian, Chen, Hao, Wu, Zhongzhi, Yang, Jinliang, White, Stephen W., Miller, Duane D., Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637749/
https://ncbi.nlm.nih.gov/pubmed/30122035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00827
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