An orally available tubulin inhibitor, VERU-111, suppresses triple-negative breast cancer tumor growth and metastasis and bypasses taxane resistance

Triple-negative breast cancer (TNBC) accounts for ~15% of breast cancer cases in the United States. TNBC has poorer overall prognosis relative to other molecular subtypes due to rapid onset of drug resistance to conventional chemotherapies and increased risk of visceral metastases. Taxanes like pacl...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Deng, Shanshan, Krutilina, Raisa I, Wang, Qinghui, Lin, Zongtao, Parke, Deanna N., Playa, Hilaire C., Chen, Hao, Miller, Duane D., Seagroves, Tiffany N., Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007836/
https://ncbi.nlm.nih.gov/pubmed/31645441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0536
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