Synthesis and biological activity of highly potent octapeptide analogs of somatostatin.

In the search for selective and long-acting analogs of somatostatin, nearly 200 compounds were synthesized by solid-phase methods, purified, and tested biologically. Among these octapeptides, some contained N-terminal (Formula: see text) were 177 times and 113 times more potent, respectively, than s...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cai, R Z, Szoke, B, Lu, R, Fu, D, Redding, T W, Schally, A V
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1986
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323191/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2869490/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.6.1896
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