Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs

Heteroduplex oligonucleotides (HDOs), composed of a DNA/LNA gapmer and its complementary RNA, are a novel, promising candidates for antisense drugs. We previously reported oligodiaminogalactoses (ODAGals), designed to bind to A-type nucleic acid duplexes such as DNA/RNA and RNA/RNA duplexes. In this...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Hara, Rintaro Iwata, Hisada, Yuki, Maeda, Yusuke, Yokota, Takanori, Wada, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847598/
https://ncbi.nlm.nih.gov/pubmed/29531343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22161-8
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