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An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability
Small interfering RNAs (siRNAs) are potential tools for gene-silencing therapy, but their instability is one of the obstacles in the development of siRNA-based drugs. To improve siRNA stability, we synthesised a double-stranded RNA-binding cationic oligodiaminogalactose 4mer (ODAGal4) and investigat...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7481297/ https://ncbi.nlm.nih.gov/pubmed/32908235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71896-w |
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