Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles

[Image: see text] We report a potent cationic lipid, SST-02 ((3-hydroxylpropyl)dilinoleylamine), which possesses a simple chemical structure and is synthesized just in one step. Cationic lipids are key components of siRNA-lipid nanoparticles (LNP), which may serve as potential therapeutic agents for...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Kuboyama, Takeshi, Yagi, Kaori, Naoi, Tomoyuki, Era, Tomohiro, Yagi, Nobuhiro, Nakasato, Yoshisuke, Yabuuchi, Hayato, Takahashi, Saori, Shinohara, Fumikazu, Iwai, Hiroto, Koubara-Yamada, Ayumi, Hasegawa, Kazumasa, Miwa, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511965/
https://ncbi.nlm.nih.gov/pubmed/31097994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00652
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