Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation

OPTN (optineurin), a ubiquitin-binding scaffold protein, functions as an important macroautophagy/autophagy receptor in selective autophagy processes. Mutations in OPTN have been linked with human neurodegenerative diseases including ALS and glaucoma. However, the mechanistic basis underlying the re...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Autophagy
Main Authors: Li, Faxiang, Xu, Daichao, Wang, Yingli, Zhou, Zixuan, Liu, Jianping, Hu, Shichen, Gong, Yukang, Yuan, Junying, Pan, Lifeng
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
Assuntos:
Research Paper - Basic Science
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846504/
https://ncbi.nlm.nih.gov/pubmed/29394115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1391970
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares