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Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism

OPTN (optineurin) is an autophagy receptor and mutations in the OPTN gene result in familial glaucoma (E50K) and amyotrophic lateral sclerosis (ALS) (E478G). However, the mechanisms through which mutant OPTN leads to human diseases remain to be characterized. Here, we demonstrated that OPTN colocali...

詳細記述

保存先:
書誌詳細
出版年:Autophagy
主要な著者: Shen, Wen-Chuan, Li, Huei-Ying, Chen, Guang-Chao, Chern, Yijuang, Tu, Pang-hsien
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502753/
https://ncbi.nlm.nih.gov/pubmed/25484089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.36098
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