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Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism

OPTN (optineurin) is an autophagy receptor and mutations in the OPTN gene result in familial glaucoma (E50K) and amyotrophic lateral sclerosis (ALS) (E478G). However, the mechanisms through which mutant OPTN leads to human diseases remain to be characterized. Here, we demonstrated that OPTN colocali...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Shen, Wen-Chuan, Li, Huei-Ying, Chen, Guang-Chao, Chern, Yijuang, Tu, Pang-hsien
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502753/
https://ncbi.nlm.nih.gov/pubmed/25484089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.36098
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