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Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
Optineurin is an important autophagy receptor involved in several selective autophagy processes, during which its function is regulated by TBK1. Mutations of optineurin and TBK1 are both associated with neurodegenerative diseases. However, the mechanistic basis underlying the specific interaction be...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027247/ https://ncbi.nlm.nih.gov/pubmed/27620379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12708 |
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