Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation

OPTN (optineurin), a ubiquitin-binding scaffold protein, functions as an important macroautophagy/autophagy receptor in selective autophagy processes. Mutations in OPTN have been linked with human neurodegenerative diseases including ALS and glaucoma. However, the mechanistic basis underlying the re...

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Dades bibliogràfiques
Publicat a:Autophagy
Autors principals: Li, Faxiang, Xu, Daichao, Wang, Yingli, Zhou, Zixuan, Liu, Jianping, Hu, Shichen, Gong, Yukang, Yuan, Junying, Pan, Lifeng
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper - Basic Science
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846504/
https://ncbi.nlm.nih.gov/pubmed/29394115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1391970
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