Urinary Mitochondrial DNA Identifies Renal Dysfunction and Mitochondrial Damage in Sepsis-Induced Acute Kidney Injury

BACKGROUND: Recent animal studies have shown that mitochondrial dysfunction initiates and accelerates renal injury in sepsis, but its role in sepsis remains unknown. Mitochondrial stress or dying cells can lead to fragmentation of the mitochondrial genome, which is considered a surrogate marker of m...

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Bibliographic Details
Published in:Oxid Med Cell Longev
Main Authors: Hu, Qiongyuan, Ren, Jianan, Ren, Huajian, Wu, Jie, Wu, Xiuwen, Liu, Song, Wang, Gefei, Gu, Guosheng, Guo, Kun, Li, Jieshou
Format: Artigo
Language:Inglês
Published: Hindawi 2018
Subjects:
Clinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846356/
https://ncbi.nlm.nih.gov/pubmed/29682165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8074936
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