The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

Disruption of the mucosal barrier following intestinal ischemia reperfusion (I/R) is life threatening in clinical practice. Mitochondrial dysfunction and oxidative stress significantly contribute to the early phase of I/R injury and amplify the inflammatory response. MitoQ is a mitochondrially targe...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Hu, Qiongyuan, Ren, Jianan, Li, Guanwei, Wu, Jie, Wu, Xiuwen, Wang, Gefei, Gu, Guosheng, Ren, Huajian, Hong, Zhiwu, Li, Jieshou
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851994/
https://ncbi.nlm.nih.gov/pubmed/29540694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0436-x
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