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Large enhancement of response times of a protein conformational switch by computational design

The design of protein conformational switches—or proteins that change conformations in response to a signal such as ligand binding—has great potential for developing novel biosensors, diagnostic tools, and therapeutic agents. Among the defining properties of such switches, the response time has been...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: DeGrave, Alex J., Ha, Jeung-Hoi, Loh, Stewart N., Chong, Lillian T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844902/
https://ncbi.nlm.nih.gov/pubmed/29523842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03228-6
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