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Modular Enzyme Design: Regulation by Mutually Exclusive Protein Folding
A regulatory mechanism is introduced whereupon the catalytic activity of a given enzyme is controlled by ligand binding to a receptor domain of choice. A small enzyme (barnase) and a ligand-binding polypeptide (GCN4) are fused so that a simple topological constraint prevents them from existing simul...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145369/ https://ncbi.nlm.nih.gov/pubmed/16483603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.01.073 |
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