MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver oncogenes are difficult to be uniquely defined. Here we report that MYC acts as tumor reprogramming factor in mammary epithelial cells by inducing an alternative epigenetic program, which triggers loss of cell ide...

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Publicado en:Nat Commun
Autores principales: Poli, Vittoria, Fagnocchi, Luca, Fasciani, Alessandra, Cherubini, Alessandro, Mazzoleni, Stefania, Ferrillo, Sara, Miluzio, Annarita, Gaudioso, Gabriella, Vaira, Valentina, Turdo, Alice, Gaggianesi, Miriam, Chinnici, Aurora, Lipari, Elisa, Bicciato, Silvio, Bosari, Silvano, Todaro, Matilde, Zippo, Alessio
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844884/
https://ncbi.nlm.nih.gov/pubmed/29523784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03264-2
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