MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver oncogenes are difficult to be uniquely defined. Here we report that MYC acts as tumor reprogramming factor in mammary epithelial cells by inducing an alternative epigenetic program, which triggers loss of cell ide...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Commun
Κύριοι συγγραφείς: Poli, Vittoria, Fagnocchi, Luca, Fasciani, Alessandra, Cherubini, Alessandro, Mazzoleni, Stefania, Ferrillo, Sara, Miluzio, Annarita, Gaudioso, Gabriella, Vaira, Valentina, Turdo, Alice, Gaggianesi, Miriam, Chinnici, Aurora, Lipari, Elisa, Bicciato, Silvio, Bosari, Silvano, Todaro, Matilde, Zippo, Alessio
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group UK 2018
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844884/
https://ncbi.nlm.nih.gov/pubmed/29523784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03264-2
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