MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver oncogenes are difficult to be uniquely defined. Here we report that MYC acts as tumor reprogramming factor in mammary epithelial cells by inducing an alternative epigenetic program, which triggers loss of cell ide...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Poli, Vittoria, Fagnocchi, Luca, Fasciani, Alessandra, Cherubini, Alessandro, Mazzoleni, Stefania, Ferrillo, Sara, Miluzio, Annarita, Gaudioso, Gabriella, Vaira, Valentina, Turdo, Alice, Gaggianesi, Miriam, Chinnici, Aurora, Lipari, Elisa, Bicciato, Silvio, Bosari, Silvano, Todaro, Matilde, Zippo, Alessio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844884/
https://ncbi.nlm.nih.gov/pubmed/29523784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03264-2
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