NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients

BACKGROUND: Macrophages play a crucial role in the interaction between tumor and immune system, and iNOS is known as a surrogate marker of M1 macrophages activation. The goal of the study was to investigate the role of iNOS polymorphisms as prognostic marker in mCRC patients. MATERIALS AND METHODS:...

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Udgivet i:PLoS One
Main Authors: Schirripa, Marta, Zhang, Wu, Yang, Dongyun, Cao, Shu, Okazaki, Satoshi, Loupakis, Fotios, Berger, Martin D., Ning, Yan, Miyamoto, Yuji, Suenaga, Mitsukuni, Alberti, Giulia, West, Jordan D., Lonardi, Sara, Khoukaz, Taline, Bergamo, Francesca, Battaglin, Francesca, Antoniotti, Carlotta, Falcone, Alfredo, Stintzing, Sebastian, Heinemann, Volker, Lenz, Heinz-Josef
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844536/
https://ncbi.nlm.nih.gov/pubmed/29522543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193640
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