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NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients

BACKGROUND: Macrophages play a crucial role in the interaction between tumor and immune system, and iNOS is known as a surrogate marker of M1 macrophages activation. The goal of the study was to investigate the role of iNOS polymorphisms as prognostic marker in mCRC patients. MATERIALS AND METHODS:...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schirripa, Marta, Zhang, Wu, Yang, Dongyun, Cao, Shu, Okazaki, Satoshi, Loupakis, Fotios, Berger, Martin D., Ning, Yan, Miyamoto, Yuji, Suenaga, Mitsukuni, Alberti, Giulia, West, Jordan D., Lonardi, Sara, Khoukaz, Taline, Bergamo, Francesca, Battaglin, Francesca, Antoniotti, Carlotta, Falcone, Alfredo, Stintzing, Sebastian, Heinemann, Volker, Lenz, Heinz-Josef
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844536/
https://ncbi.nlm.nih.gov/pubmed/29522543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193640
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