Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β(1) subunit

Thiazide-like diuretics are the most commonly used drugs to treat arterial hypertension, with their efficacy being linked to their chronic vasodilatory effect. Previous studies suggest that activation of the large conductance voltage- and Ca(2+)-dependent K(+) (BK) channel (Slo 1, MaxiK channel) is...

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Detaylı Bibliyografya
Yayımlandı:Acta Pharmacol Sin
Asıl Yazarlar: Martín, Pedro, Moncada, Melisa, Kuntamallappanavar, Guruprasad, Dopico, Alex M, Milesi, Verónica
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2018
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843832/
https://ncbi.nlm.nih.gov/pubmed/29188803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.133
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