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Alcohol modulation of BK channel gating depends on β subunit composition

In most mammalian tissues, Ca(2+)(i)/voltage-gated, large conductance K(+) (BK) channels consist of channel-forming slo1 and auxiliary (β1–β4) subunits. When Ca(2+)(i) (3–20 µM) reaches the vicinity of BK channels and increases their activity at physiological voltages, β1- and β4-containing BK chann...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Kuntamallappanavar, Guruprasad, Dopico, Alex M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089933/
https://ncbi.nlm.nih.gov/pubmed/27799321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611594
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