Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β(1) subunit

Thiazide-like diuretics are the most commonly used drugs to treat arterial hypertension, with their efficacy being linked to their chronic vasodilatory effect. Previous studies suggest that activation of the large conductance voltage- and Ca(2+)-dependent K(+) (BK) channel (Slo 1, MaxiK channel) is...

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Bibliographic Details
Published in:Acta Pharmacol Sin
Main Authors: Martín, Pedro, Moncada, Melisa, Kuntamallappanavar, Guruprasad, Dopico, Alex M, Milesi, Verónica
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2018
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843832/
https://ncbi.nlm.nih.gov/pubmed/29188803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.133
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