Guanylate cyclase 2C agonism corrects CFTR mutants

Cystic fibrosis (CF) is a genetic disorder in which epithelium-generated fluid flow from the lung, intestine, and pancreas is impaired due to mutations disrupting CF transmembrane conductance regulator (CFTR) channel function. CF manifestations of the pancreas and lung are present in the vast majori...

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Publicado en:JCI Insight
Main Authors: Arora, Kavisha, Huang, Yunjie, Mun, Kyushik, Yarlagadda, Sunitha, Sundaram, Nambirajan, Kessler, Marco M., Hannig, Gerhard, Kurtz, Caroline B., Silos-Santiago, Inmaculada, Helmrath, Michael, Palermo, Joseph J., Clancy, John P., Steinbrecher, Kris A., Naren, Anjaparavanda P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841874/
https://ncbi.nlm.nih.gov/pubmed/28978796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93686
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