Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine

The transmembrane receptor guanylyl cyclase‐C (GC‐C), expressed on enterocytes along the intestine, is the molecular target of the GC‐C agonist peptide linaclotide, an FDA‐approved drug for treatment of adult patients with Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipatio...

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Detaylı Bibliyografya
Yayımlandı:Physiol Rep
Asıl Yazarlar: Ahsan, Md. Kaimul, Tchernychev, Boris, Kessler, Marco M., Solinga, Robert M., Arthur, David, Linde, Cristina I., Silos‐Santiago, Inmaculada, Hannig, Gerhard, Ameen, Nadia A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471438/
https://ncbi.nlm.nih.gov/pubmed/28592587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13299
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