Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine

The transmembrane receptor guanylyl cyclase‐C (GC‐C), expressed on enterocytes along the intestine, is the molecular target of the GC‐C agonist peptide linaclotide, an FDA‐approved drug for treatment of adult patients with Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipatio...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Ahsan, Md. Kaimul, Tchernychev, Boris, Kessler, Marco M., Solinga, Robert M., Arthur, David, Linde, Cristina I., Silos‐Santiago, Inmaculada, Hannig, Gerhard, Ameen, Nadia A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471438/
https://ncbi.nlm.nih.gov/pubmed/28592587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13299
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