Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis

Alzheimer’s disease (AD) is characterized by two neuropathological hallmarks: senile plaques, which are composed of amyloid-β (Aβ) peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated tau protein. Aβ peptides are derived from sequential proteolytic cleavage of the amyloid...

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Veröffentlicht in:Cell Death Discov
Hauptverfasser: Matthes, Frank, Hettich, Moritz M., Schilling, Judith, Flores-Dominguez, Diana, Blank, Nelli, Wiglenda, Thomas, Buntru, Alexander, Wolf, Hanna, Weber, Stephanie, Vorberg, Ina, Dagane, Alina, Dittmar, Gunnar, Wanker, Erich, Ehninger, Dan, Krauss, Sybille
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841321/
https://ncbi.nlm.nih.gov/pubmed/29531801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-017-0003-8
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