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Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis

Bioenergetic failure and oxidative stress are common pathological hallmarks of amyotrophic lateral sclerosis (ALS), but whether these could be targeted effectively for novel therapeutic intervention needs to be determined. One of the reported contributors to ALS pathology is mitochondrial dysfunctio...

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Pubblicato in:EMBO Mol Med
Autori principali: Joshi, Amit U, Saw, Nay L, Vogel, Hannes, Cunnigham, Anna D, Shamloo, Mehrdad, Mochly‐Rosen, Daria
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840540/
https://ncbi.nlm.nih.gov/pubmed/29335339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708166
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