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Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington’s disease.

Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder, best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances, is caused by CAG-repeat expansion in exon 1 of Huntingtin (HTT). However, in addition to the neurologic...

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Bibliografische gegevens
Gepubliceerd in:J Mol Cell Cardiol
Hoofdauteurs: Joshi, A.U., Ebert, A.E., Haileselassie, B., Mochly-Rosen, D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894172/
https://ncbi.nlm.nih.gov/pubmed/30550751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.12.004
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