Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening

Protein arginine methyltransferase 5 (PRMT5) is able to regulate gene transcription by catalyzing the symmetrical dimethylation of arginine residue of histone, which plays a key role in tumorigenesis. Many efforts have been taken in discovering small-molecular inhibitors against PRMT5, but very few...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Wang, Qianqian, Xu, Jiahui, Li, Ying, Huang, Jumin, Jiang, Zebo, Wang, Yuwei, Liu, Liang, Leung, Elaine Lai Han, Yao, Xiaojun
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838003/
https://ncbi.nlm.nih.gov/pubmed/29545752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00173
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