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Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases
Protein arginine methyltransferases (PRMTs) are essential epigenetic and post-translational regulators in eukaryotic organisms. Dysregulation of PRMTs is intimately related to multiple types of human diseases, particularly cancer. Based on the previously reported PRMT1 inhibitors bearing the diamidi...
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| 出版年: | RSC Med Chem |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
RSC
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8130551/ https://ncbi.nlm.nih.gov/pubmed/34046601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00259c |
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