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Pharmacophore-Based Virtual Screening and Biological Evaluation of Small Molecule Inhibitors for Protein Arginine Methylation

Protein arginine methyltransferases (PRMTs) are proved to play vital roles in chromatin remodeling, RNA metabolism and signal transduction. Aberrant regulation of PRMT activity is associated with various pathological states such as cancer and cardiovascular disorders. Development and application of...

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Detalhes bibliográficos
Main Authors: Wang, Juxian, Chen, Limin, Sinha, Sarmistha Halder, Liang, Zhongjie, Cai, Huifang, Muniyan, Sakthivel, Chou, Yu-Wei, Yang, Chao, Li, Keqin Kathy, Lin, Ming-Fong, Jiang, Hualiang, Zheng, Yujun George, Luo, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150255/
https://ncbi.nlm.nih.gov/pubmed/22928876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300521m
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