Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening

IDH1 mutations occur in about 20–30% of gliomas and are a promising target for the treatment of cancer. In the present study, the performance of aIDH1(R132H) was verified via glide-docking-based virtual screening. On the basis of the two crystal structures (5TQH and 6B0Z) with the best discriminatin...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Wang, Yuwei, Tang, Shuai, Lai, Huanling, Jin, Ruyi, Long, Xu, Li, Na, Tang, Yuping, Guo, Hui, Yao, Xiaojun, Leung, Elaine Lai-Han
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686577/
https://ncbi.nlm.nih.gov/pubmed/33262701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.579768
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